Connecting Chromatin Modifying Factors to DNA Damage Response
نویسندگان
چکیده
منابع مشابه
Connecting Chromatin Modifying Factors to DNA Damage Response
Cells are constantly damaged by factors that can induce DNA damage. Eukaryotic cells must rapidly load DNA repair proteins onto damaged chromatin during the DNA damage response (DDR). Chromatin-remodeling complexes use the energy from ATP hydrolysis to remodel nucleosomes and have well-established functions in transcription. Emerging lines of evidence indicate that chromatin-remodeling complexe...
متن کاملChromatin modulation and the DNA damage response.
The ability to sense and respond appropriately to genetic lesions is vitally important to maintain the integrity of the genome. Emerging evidence indicates that various modulations to chromatin structure are centrally important to many aspects of the DNA damage response (DDR). Here, we discuss recently described roles for specific post-translational covalent modifications to histone proteins, a...
متن کاملChromatin modifications and the DNA damage response to ionizing radiation
In order to survive, cells have evolved highly effective repair mechanisms to deal with the potentially lethal DNA damage produced by exposure to endogenous as well as exogenous agents. Ionizing radiation exposure induces highly lethal DNA damage, especially DNA double-strand breaks (DSBs), that is sensed by the cellular machinery and then subsequently repaired by either of two different DSB re...
متن کاملRemodelers move chromatin in response to DNA damage
DNA double-strand breaks (DSBs) are dangerous lesions that occur when both strands of the DNA double helix are broken. Repair of DSBs occurs either by homologous recombination (HR) or non-homologous end-joining (NHEJ). A fundamental distinction between the 2 pathways lies in the requirement for a homologous sequence that templates the repair: this is needed for HR but not for NHEJ. In S-phase c...
متن کاملAnalysis of chromatin integrity and DNA damage of buffalo spermatozoa
This study was conducted to determine chromatin integrity and DNA damage by DNA electrophoresis and comet assays of buffalo fresh and frozen semen. Semen samples were collected from four buffalo bulls and evaluated after freezing for semen motility, viability, sperm abnormalities, chromatin integrity and DNA damage. A significant variation was found in semen parameters after thawing. Highly sig...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2013
ISSN: 1422-0067
DOI: 10.3390/ijms14022355